In this 27-year, population-based case-control study of 3 761 618 children in Denmark, the odds were nearly 4-fold higher of opioid-related death and nearly 3-fold higher of any SOE among children whose family members filled an opioid prescription in the prior 3 months compared with children in unexposed households, and the odds were also higher compared with children exposed to nonopioid analgesics.

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